The exposure of DU145 cells to 64Cu did not induce a consistent overexpression of stress genes involved in hypoxia responses (data not shown), unlike HCT116 tumor cells for which 64CuCl2 induced the upregulation of the hypoxia-responsive genes HMOX1 and MMP9, as presented in Figure 9C. The gene discussed is HMOX1; the disease is neoplasm.