By a cell-by-cell immunohistochemical analysis in colorectal cancer (CRC) and liver metastases resected after chemotherapy with oxaliplatin, Rotoli et al. showed a molecular interaction between the scaffold proteins angiomotin-like 2 (AmotL2), FKBP51, and IQ motif containing GTPase-activating protein 1 (IQGAP1) proteins within the EMT context of cancer tissues [56]. This evidence concerns the gene AMOTL2 and colorectal cancer.