SPARC and melanoma: By co-immunoprecipitation assays, Romano et al. found that FKBP51 interacts with the general transcriptional co-activator p300 and the TGF-β transcription factors Smad2/3 [55] and promotes some transcriptional activities of the TGF-β, precisely the gene expression of vimentin (VIM) and secreted protein acidic and cysteine-rich (SPARC), associated with accelerated tumor growth, invasion, and poor prognosis of melanoma [55].