In this study, we used a gene list including 274 PANRGs, and LASSO-Cox regression analysis was used to screen a risk prognostic model PANscore consisting of 8 PANoptosis-related genes (including DAP3, LGALS3, PPP2R5B, HSP90AA1, MYCN, PLK1, SQSTM1, and GSDME) to support the prediction of HCC prognosis. The gene discussed is PLK1; the disease is hepatocellular carcinoma.