MFN2 and Hyperglycemia: The effect of mitofusin on mitophagy is considered to be context-dependent, and its responsiveness can vary in different cell conditions; consistent with our results showing amelioration of hyperglycemia-induced decrease in autophagosome formation-mitophagy by Mfn2 overexpression, downregulation of Mfn2 is associated with decrease in mitophagy in coronary heart disease (8).