Amelioration of high glucose-induced decrease in autopahagosome formation- mitophagy flux by resveratrol in retinal endothelial cells is further supported by others showing the role of Sirt1-Mfn2 axis in mitochondrial homeostasis (17, 18), and Sirt1 inhibition reducing Mfn2-mediated mitophagy in gastric cancer (18). The gene discussed is MFN2; the disease is gastric cancer.