NLRP6 and colorectal carcinoma: Additionally, in the context of obesity, the downregulation of NLRP6 levels in the colon of CRC patients lowers the integrity of the intestinal barrier, causes local inflammation, and then acts on obese patients' dysfunctional adipocytes, increasing the expression of various inflammasome components and causing an uncontrollable vicious cycle of inflammation that is favorable to the development of tumor microenvironment [35].