ACE2 and obesity due to melanocortin 4 receptor deficiency: Due to the critical role of ACE2 in SARS-CoV-2 infection, it is proposed that the altered RAAS and KKS stability may lead, in part, to adverse outcomes and increased risk of mortality in COV patients, especially in individuals with pre-existing comorbidities such as hypertension, diabetes, and obesity [15,28,29].