Additionally, pathogenic variants in WFS1 can cause the development of WFS1-related disorders involving sensorineural low frequency hearing loss, hearing loss and optic atrophy, cataracts, and an autosomal dominant syndrome characterized by neonatal diabetes, congenital cataracts, sensorineural deafness, hypotonia, intellectual disability, and development delay (De Franco et al., 2017). The gene discussed is WFS1; the disease is Leber hereditary optic neuropathy.