Results: The lead signals, rs9265901 on the 5’ end of HLA-B, rs55888430 on HLA-DOB, and rs117953947 on HCG17, were significantly associated with late-onset asthma in all, White, and Black participants, respectively (OR = 1.73, 95%CI: 1.31 to 2.14, p = 3.62 × 10−5; OR = 3.05, 95%CI: 1.86 to 4.98, p = 8.85 × 10−6; OR = 19.5, 95%CI: 4.37 to 87.2, p = 9.97 × 10−5, respectively). This evidence concerns the gene HLA-B and asthma.