TNF and COVID-19: The etiology of the Leser–Trélat sign is still unknown, it is likely that viral infections like COVID‐19 can be associated with eruptive seborrheic keratosis, although the exact pathogenesis is still not clear, but this phenomenon can be due to TNF‐alpha and TGF‐alpha and immunosuppression condition as well as in COVID‐19 infection.