In the literature, Peckova et al. and Caliò et al. described five tumours with TFEB t(6;11) with recurrence or metastasis.3,4,26 Morphologically, most patients had large primary tumour size, occurred in older patients and often showed grossly visible necrosis.3,4 Importantly, these aggressive tumours also had TFEB amplification, a genetic alteration associated with more aggressive behaviour27,28 emphasizing the necessity to distinguish them from purely TFEB translocated tumors. Here, TFEB is linked to neoplasm.