FTO and hepatocellular carcinoma: RANBP2, a SUMOylation E3 ligase, mediates Fat mass- and obesity-associated gene (FTO) SUMOylation and subsequent degradation, inducing Guanine nucleotide-binding protein G (o) subunit alpha (GNAO1) instability, an m6A substrate of FTO and a tumor suppressor in HCC [52].