SUMO conjugations to target proteins are blocked by these compounds since they impair the formation of the SAE1/2-SUMO intermediate [189, 190]. A phenol in Ginkgo biloba L. named Ginkgolic acid was known to have antibacterial and antitumor properties through its targeting of proinflammatory factors such as prostaglandins and leukotrienes, suppressing the pro-tumor inflammatory microenvironment formation [191]. This evidence concerns the gene SAE1 and neoplasm.