SENP3 and SENP5 were found overexpressed and related to differentiation of OSCC [38, 39]. A germline variant of minichromosome maintenance proteins (MCMs) can increase its SUMOylation levels, facilitating Esophageal squamous cell carcinoma (ESCC) proliferation and metastasis [40]. The gene discussed is SENP5; the disease is esophageal squamous cell carcinoma.