In this regard, (1) elevated and unregulated levels of the second-messenger calcium has long been observed in cancer; (2) the possible role of type II proteins in intracellular calcium homeostasis via calsequestrin binding was recently suggested [4] and, (3) labyrinthin expression was increased in A549 cells exposed to elevated calcium [17], indicating some interplay between calcium and labyrinthin. The gene discussed is SGCG; the disease is cancer.