In NSCLC cells, anti‐CTLA-4 antibody was able to induce PD‐L1 expression and to promote NSCLC cell proliferation and tumor growth in the absence of adaptive immunity, suggesting that tumor cell‐intrinsic CTLA-4 can regulate PD‐L1 expression and cell proliferation in cancer cells [36]. The gene discussed is CTLA4; the disease is cancer.