And no significant multiplicative or additive effects between BPH/PV PRS and hereditary gene mutations (BRCA2 and PALB2) were detected (Pmultiplicative = 0.65, Padditive = 0.71), as well as with DDR gene carriers (Pmultiplicative = 0.88, Padditive = 0.66). The gene discussed is PALB2; the disease is benign prostatic hyperplasia.