THRB and metabolic dysfunction-associated steatotic liver disease: Moreover, recent studies found that TGR5 prefers to influence NAFLD-related hypothyroidism regardless of the level of thyroid hormone [142], and researchers found that thyroid hormone β receptor (TRβ) regulates the synthesis of BAs by interfering with SHP [143, 144] or CYP7A1 directly in the liver [145].