No known mutations were detected in the genes associated with tauopathies and FTD/amyotrophic lateral sclerosis, including MAPT, LRRK2, C9ORF72, ANG, ARGHEF28, CDH13, CHMP2B, FUS, GRN, HNRNPA1, PSEN1, PSEN2, SOD1, SQSTM1, TARDBP, TREM2, UBQLN2, VAPB, and VCP. The gene discussed is PSEN1; the disease is amyotrophic lateral sclerosis.