The mean (SD) global health score in patients with BBS was similar across all weight classes (overweight, 38.9 [8.2]; obesity class I, 36.5 [10.4]; obesity class II, 36.6 [10.9]; obesity class III, 36.5 [11.4]). The gene discussed is BBS2; the disease is obesity due to melanocortin 4 receptor deficiency.