Responses from the IWQOL-Kids Parent Proxy demonstrated obesity had a negative impact on all health-related quality of life domains, with the greatest impact on physical comfort (mean [SD], 41.7 [17.2]), body esteem (41.0 [17.8]), and social life (41.7 [18.0]) in pediatric patients with BBS and overweight or obesity (Table 3). Here, BBS2 is linked to obesity due to melanocortin 4 receptor deficiency.