Indeed, the tumor-microenvironment and inflammation mediated SE at PDZK1IP1 may fall into this latter category—ubiquitous in primary CRC, yet rare in CRC cell lines (purely cell-intrinsic) as well as inflamed non-dysplastic colon (purely cell-extrinsic) [114]. This evidence concerns the gene PDZK1IP1 and colorectal carcinoma.