Alternatively, a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF chromatin remodeling complex ATPase subunits SMARCA2 and SMARCA4 was recently observed to deplete H3K27ac at several oncogenic SEs, including at MYC, AR, ERG, and FOXA1, resulting in potent suppression of prostate cancer growth in xenograft models [153]. The gene discussed is ERG; the disease is prostate cancer.