Previous studies have suggested that the differential distribution of the ECM proteins - fibronectin, tenascin, laminin, and collagen IV - in the cyst wall is responsible for the aggressive behavior of syndromic OKC [21], and fibroblasts in the cyst wall may also modulate the aggressive behavior by regulating ECM properties or epithelial-mesenchymal interactions [22]. This evidence concerns the gene LAMB2 and cyst.