Next, we generated stable DRD2 down-regulation and over-expression glioma cells (sFig.3A) and found that DRD2 down-regulation significantly inhibited glioma cell growth, while DRD2 over-expression significantly promoted the aforementioned effect in both U251, GBM#2 and U87 cells (Fig. 3A-3D, sFig.3B-3F). Here, DRD2 is linked to glioma.