Next, since DRD2 down-regulated cells generated by shDRD2 in Fig. 3A grew extremely slow, we performed the above experiment in vivo by conducting the xenograft tumor model with doxycycline-inducible DRD2 knockdown (shDRD2i) GBM#2 cells (sFig.4F,4G) together with CRS treatment (Fig. 3I). This evidence concerns the gene DRD2 and neoplasm.