Conversely, M2 (F4/80+CD11b+CD206+) inhibits the activity of T-cells and NK cells by expressing ARG-1, IL-10, and TGF-β, induces angiogenesis and promotes tumor growth and invasion by expressing VEGF and matrix metal protein (MMP), and can also generate chemokines such as CCL2 and CCL5 to recruit regulatory T-cells (Tregs). This evidence concerns the gene ITGAM and neoplasm.