AngII depends on AngII-AGTR1A signal transduction in hematopoietic cells to suppress the signaling between sphingosine-1-phosphate receptor 1 and sphingosine-1-phosphate and significantly increases the retention of HSCs in the spleen, thus amplifying the macrophage progenitor response in vivo and consequently facilitating the supply of TAM in the spleen during cancer progression. The gene discussed is AGT; the disease is cancer.