We investigated the kinase that phosphorylated Runx2 by examining LPS-IVDs and LPS-treated NP/AF cells for the presence of several kinases, including p38, extracellular signal-regulated kinase 1 (ERK1), ERK2, and c-Jun N-terminal kinase 1 (JNK1). The gene discussed is MAPK3; the disease is atrial fibrillation.