For example, Xu et al. fabricated nanodiamond-polyglycerol-doxorubicin conjugates (nano-DOX) and found that nano-DOX could induce PD-L1 in NSCLC cells and PD-1 in TAMs through the activation of the HMGB1/RAGE/NF-κB pathway [56]. Here, CD274 is linked to non-small cell lung carcinoma.