EGF and neoplasm: This method significantly increased the accumulation of EGF@DOX-NPs in the tumor tissues (0.68 ± 0.08 μg/mL of RT + EGF@DOX-NPs vs. 0.11 ± 0.07 μg/mL of free DOX) which resulted in superior tumor inhibition effects (Fig. 2B,C) [48].