The most common all-grade AEs included aspartate transaminase (AST) increase, alanine aminotransferase (ALT) elevation, proteinuria, hypertension, fatigue, thrombocytopenia, appetite loss, pyrexia, peripheral edema, pruritus, nausea, rash, and blood bilirubin increase (Table 3). This evidence concerns the gene GPT and hypertensive disorder.