The incidence of grade ≥ 3 AEs was 30%, and the common grade 3 and above AEs were as follows: AST increase (5%), hypertension (5%), proteinuria (4%), ALT elevation (3%), gastrointestinal hemorrhage (3%), thrombocytopenia (2%), and blood bilirubin increase (2%). This evidence concerns the gene GPT and hypertensive disorder.