TGFB1 and metabolic dysfunction-associated steatotic liver disease: Subset C4 was a predominantly liver fibrosis subtype, in which the enrichment scores for fibrosis transcriptomic signature, HSC-associated transcriptomic signatures and TGF-β signature were significantly higher than other NAFLD subsets, and patients in this subset had more advanced liver fibrosis or a higher risk of liver fibrosis progression than other NAFLD subsets (Fig. 3C).