Though we cannot exclude the possibility that Rbfox2 regulates other genes AS events in heart, like guanine exchange factors of Rho GTPase family proteins [26], the presented data revealed that Rbfox2 indeed induce cardiac hypertrophy, which is, at least partly, mediated by regulating CaV1.2 AS events. The gene discussed is CACNA1C; the disease is cardiac hypertrophy.