ER stress can increase the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and monoclonal antibody to Suppressor of Mothers against Decapentaplegic (SMAD) family member 3 (Smad3), and also activate UPS‐mediated proteolysis to promote sepsis‐induced muscle atrophy (Zheng et al. 2023). This evidence concerns the gene STAT3 and Sepsis.