SLC5A1 and obesity due to melanocortin 4 receptor deficiency: For example, Nishimura et al. discovered that suppression of O-GlcNAcylation in the intestine reduced glucose absorption via inhibiting SGLT1 expression, suggesting that regulating O-GlcNAcylation in the intestine may provide a novel strategy for treating absorption disorders, obesity, and diabetes (Nishimura et al. 2022).