In summary, we report 2 cases of a high-grade tumor diagnosed as non-ITAC of the sinonasal region, characterized by overt hypercellularity, largely solid growth pattern with comedo-like necrosis, immunohistochemical positivity for p40/p63, S100, SOX10, and GATA3, with a recurrent ETV6::NTRK3 fusion. Here, NTRK3 is linked to neoplasm.