Together with the decreases in blood pressure and urinary noradrenaline excretion in SHRSPs in which RVLM astrocytes were transduced with the Agtrap gene (Fig. 3d−f), the intensity of AT1R signalling in RVLM astrocytes seems to be critically involved in the pathogenesis of hypertension and sympathetic hyperactivity in SHRSPs. Here, AGTR1 is linked to hypertensive disorder.