Disease groups more likely to have a low or absent serological response (compared to the healthy control group) included ANCA-associated vasculitis (OR: 0.03, 95% CI 0.01–0.13), inflammatory arthritis (OR: 0.45, 95% CI 0.27–0.77), hemodialysis (OR: 0.29, 95% CI 0.16–0.51), kidney transplant (OR: 0.26, 95% CI 0.12–0.57), Crohn’s disease (OR: 0.42, 95% CI 0.23–0.76), allo-HSCT (OR: 0.25, 95% CI 0.14–0.46) and CAR-T (OR: 0.03, 95% CI 0–0.2). The gene discussed is CARTPT; the disease is Crohn disease.