To investigate the relationships between CT imaging features, RUNX3 methylation levels, and survival in clear cell renal cell carcinoma (ccRCC), Cen et al. [53] constructed a model of renal clear cell carcinoma and discovered that the presence of indistinct tumour margins, left-sided tumours, and intra-tumour vessels significantly predicted the elevation of RUNX3 methylation levels. This evidence concerns the gene RUNX3 and nonpapillary renal cell carcinoma.