However, soft tissue sarcoma also harbors more mutations in chromatin modeler genes (e.g., ARID1A and KMT2D) and the neurotrophic tyrosine kinase receptor gene NTR1, as well as higher panel-specific TMB, compared to histiocytic sarcoma (Fig. 4). The gene discussed is KMT2D; the disease is histiocytic sarcoma.