CPSF6 and infection: Interestingly, an HIV-1 virus with the cyclosporin A (CsA)-dependent capsid mutant A92E showed decreased formation of CPSF6 condensates, which was rescued by the addition of CsA (Fig. 1B), and the increase in HIV-1-A92E infection with CsA was proportional to the formation of nuclear CPSF6 condensates.