MG53 has originally been reported to play an important role in membrane repair,25,26 which has inspired the application of recombinant MG53 protein (rhMG53) in treating acute injury of a variety of organs.30,31,47–49 In a recent study using mouse xenograft model of colorectal cancer cell SW620/AD300, injection of rhMG53 inhibits tumor growth and displays synergistic antitumor effect with doxorubicin.42 We showed significant therapeutic effects of adenoviral delivery of MG53 in delaying HCT116 tumor progression in vivo. Here, TRIM72 is linked to colorectal cancer.