Thus, increases in MG53 expression contribute to metabolic disorders by impairing insulin signaling and glucose metabolism.23,24 On the other hand, MG53 facilitates membrane repair25,26 and activates survival signaling pathways,25,27,28 and thereby playing a protective role against acute damage of multiple organs.29–31 An unbiased screening has identified MG53 as one of the 4 essential regulators that limits the proliferation and metastasis of non-small cell lung cancer,32 however how MG53 functions as tumor suppressor is unclear. This evidence concerns the gene TRIM72 and metabolic disease.