In the AOM/DSS-induced mouse colorectal cancer model, cyclin D1 was decreased in the tumors from MG53-TG mice (Fig. 6a and Supplementary Fig. 5c), but increased in those from the MG53-KO mice (Fig. 6b), relative to their corresponding wild type littermates, reinforcing the role of MG53 in facilitating cyclin D1 degradation. The gene discussed is CCND1; the disease is infectious otitis media.