In the AOM/DSS-induced mouse colorectal cancer model, cyclin D1 was decreased in the tumors from MG53-TG mice (Fig. 6a and Supplementary Fig. 5c), but increased in those from the MG53-KO mice (Fig. 6b), relative to their corresponding wild type littermates, reinforcing the role of MG53 in facilitating cyclin D1 degradation. Here, TRIM72 is linked to colorectal cancer.