In this work, we report a function of H1.2 as a brake on beige adipocyte, and the effects of adipocyte H1.2-Il10rα axis on browning and metabolic states (Fig. 10m), which may involve in the pathogenesis of obesity related metabolic diseases and warrant future study. The gene discussed is IL10RA; the disease is obesity due to melanocortin 4 receptor deficiency.