EEF2 and Alzheimer disease: In brief, we showed that in (post-mortem) brains of PD and AD, the expression and activity of eukaryotic elongation-factor 2 kinase (eEF2K) is significantly increased, both at the level of mRNA expression and also at the level of substrate phosphorylation (Immunohistochemistry- IHC detection of p-eEF2, Thr56)26,27.