SNCA and Parkinson disease: In this regard, considerable progress has been made for the biochemical and/or brain imaging-based detection of the classical markers of neuropathology (or their post-translationally modified forms such as phosphorylation), e.g., α-synuclein (gene symbol, SNCA) in PD and other synucleinopathies, β-amyloid in AD, tau in tauopathies (gene symbol, MAPT) or indicators of parenchymal damage (e.g., neurofilament ligh chain, gene symbol NEFL)7.