Of the five MOBILE-hypothesized connector genes (BST2, CLIC2, FAM83D, ACSL5, and HIST2H2AA3) between IRF1 and PD-L1, BST2 was recently recognized as part of an immune/tumor-related signature that is significantly associated with the overall survival of skin cancer patients104. This evidence concerns the gene ACSL5 and skin neoplasm.