While genetic mutations in classical cancer pathways (e.g., CDKN2A-MDM2-p53, PTEN-PI3K-AKT-mTOR, Ras-Raf-MEK) are rare in primary hepatoblastomas at diagnosis, our screen results show that ABC-Myc tumor cells depend on them, suggesting that they may be dysregulated in other ways in hepatoblastoma and/or play important roles in cancer progression and relapsed disease. Here, MDM2 is linked to cancer.