Particularly, we found that the Hippo signaling pathway is essential to ABC-Myc cell survival, in line with previous studies which demonstrate that YAP1 and TAZ promote and maintain tumorigenesis of hepatoblastoma21,22,121, supporting that our ABC-Myc model can be faithfully applied to identify hepatoblastoma-related oncogenic pathways. The gene discussed is MYC; the disease is hepatoblastoma.