MYC and neoplasm: Multifocal to coalescing neoplastic foci with an embryonal morphology could be observed in the livers of P7 ABC-Myc mice (Fig. 1e), consistent with the hypothesis that hepatoblastoma-like neoplasia may arise from epithelial-lineage committed hepatic stem progenitor cells with the introduction of human oncogenic Myc signaling resulting in impaired differentiation.