Carrillo-Reixach et al. recently identified the DLK1-DIO3 locus genes on 14q32 as a new hallmark of human hepatoblastoma that is associated with Wnt/β-catenin signaling, and high expression of 14q32 gene signature being associated with a poor outcome15, supporting that hepatoblasts could be the cells of origin of ABC-Myc hepatoblastoma. This evidence concerns the gene DLK1 and hepatoblastoma.