Compared with age-matched normal livers, the hepatoblastoma embryonic gene markers (i.e., Lin28b, Sall4, EpCAM, Hmga, Afp) in ABC-Myc tumors, which are usually associated with a poor outcome9, were increased over 4–250 fold (Fig. 3a, Supplementary Data 1). This evidence concerns the gene LIN28B and aneurysmal bone cyst.