Nevertheless, this murine model also contains histologic features of the subclassification of pediatric hepatoblastomas with hepatocellular carcinoma features that were previously called transitional liver cell tumors (TLCT)9.The phenotypic plasticity that is observed in this Myc-driven murine model of hepatoblastoma is documented in pediatric hepatoblastoma where some hepatoblastomas can be classed into the transcriptomic subgroup “liver progenitor” differentiation state that appears to correlate with the C2A molecular for human hepatoblastomas. Here, MYC is linked to hepatocellular carcinoma.