FLT3 and pericardial effusion: The reduction of risk of pleural and pericardial effusion can be achieved by dose reduction of drugs such as nilotinib, ponatinib, or FLT3 inhibitors or using a single dose of dasatinib in a day.60 When effusion occurs, apart from discontinuing dasatinib, diuretics or a short course of steroids can be helpful for reversal.146 Emergency pericardiocentesis is required in response to a large pericardial effusion (≥2 cm) of hemodynamic significance or less emergent for the diagnosis.