HFA of the ESC Cardio-Oncology Study Group in collaboration with the ICOS had developed a baseline CV risk assessment proformas for seven cardiotoxic cancer therapy classes known to cause a range of CV toxicities.28 Separate proformas are used for these seven drug classes including Anthracycline chemotherapy, HER2 targeted therapies, VEGFIs, MKIs for CML targeting BCR-ABL, MKIs for CML targeting BCR-ABL, Proteasome inhibitors (PIs) and immunomodulatory drugs (IMIDs), Combination RAF and MEK inhibitor treatment, Androgen deprivation therapies (ADT), Immune checkpoint inhibitors. This evidence concerns the gene ERBB2 and chronic myelogenous leukemia, BCR-ABL1 positive.