The primary mechanisms of QTc prolongation and cardiac arrhythmias associated with TKIs are postulated to be an off-target blockade of the human Ether-à-go-go-Related Gene (hERG) encoded potassium (K+) channel proteins in CMs which carries the repolarizing rapid delayed rectifier (IKr) current. Here, KCNH2 is linked to chronic obstructive pulmonary disease.