Five weeks after transplantation, the xenograft tumours derived from Hep3B-KD cells were significantly smaller than those derived from control cells, while the tumours in the PLC/PRF/5-OE group were larger than those in the PLC/PRF/5-Con group (Fig. 2L, M, Supplementary Fig. S2I). Here, HSPG2 is linked to neoplasm.