That HDAC1 suppresses EMT in a deacetylase-dependent manner, uncovered in the current study, is further supported by our finding that the histone acetylase p300 promotes EMT in epithelial and carcinoma organoids, as well as increased TGFβ-induced breast cancer cell migration, a key functional consequence of EMT. Here, TGFB1 is linked to breast carcinoma.