In both the T24 and 5637 cell lines, S100A5 knockdown significantly enhanced the ability of T lymphocyte (activated from human peripheral blood mononuclear cells, PBMCs) to kill cancer cells (Figure 3G, T24; Figure S20A, 5637, Supporting Information), whereas S100A5 overexpression significantly inhibited this ability (Figure 3H, T24; Figure S20B, 5637, Supporting Information). This evidence concerns the gene S100A5 and cancer.