S100 family proteins, as a type of small molecular EF‐hand calcium‐binding proteins, play vital roles in the development and progression of numerous types of carcinomas and show prognostic value and are potential novel targets for treatment.[60] The vital role of S100 proteins in carcinomas has been widely reported in melanoma, breast carcinoma, and lung carcinoma. This evidence concerns the gene S100B and lung carcinoma.