We selected four important immune checkpoints, including PD‐L1, CTLA‐4, PD‐1, and lymphocyte activation gene‐3 (LAG‐3), and found that S100A5 had the most exclusive association with these immune checkpoints in BLCA (Figure S3B–E, Supporting Information). The gene discussed is PDCD1; the disease is bladder transitional cell carcinoma.