PDCD1 and neoplasm: divided CD8+ T cells into progenitor exhausted T cells and terminally exhausted T cells, and revealed that patients with more progenitor exhausted T cells had a higher tumor‐killing efficiency and anti‐PD1 response rate.[55, 56] We found that T cell cluster 1 had significantly lower progenitor exhaustion scores and higher exhaustion scores than cluster 3 (Figure S18D, Supporting Information); therefore, we defined cluster 1 as composed of terminally exhausted CD8+ T cells and cluster 3 as composed of progenitor exhausted CD8+ T cells (Figure S18E, Supporting Information).