The TME is composed of tumor cells, fibroblast cells, vascular endothelial cells, immune cells, extracellular matrix, and extracellular soluble molecules, and plays a vital role in cancer development and evasion of the host immune system.[8] Based on the presence or absence of T cells in the tumor parenchyma, the TME can generally be divided into two profiles: non‐inflamed and inflamed tumors.[9] In this study, we used systematic bioinformatics analysis (including bulk RNA‐seq and scRNA‐seq) to reveal that S100A5 is associated with a non‐inflamed TME phenotype in BCLA. Here, S100A5 is linked to cancer.