In fact, loss-of-function variants of the gene encoding IL-36Ra (IL36RN) are associated with generalized pustular psoriasis (GPP), a potentially life-threatening skin disorder presenting with recurrent pustular eruptions and systemic upset (Marrakchi et al., 2011; Onoufriadis et al., 2011). Here, IL36RN is linked to psoriasis 14, pustular.