PFKFB3 and thyroid cancer: Just recently, Aurora-A was shown to phosphorylate the multifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, PFKFB3, on S461, which generates fructose 2,6-bisphosphate, an allosteric activator of 6-phosphofructo-1-kinase (PFK1) and rate-limiting enzyme in glycolysis [216], causing thyroid cancer progression.