ALK and neuroblastoma: Mutations to F1174 (L/S/I/C/V substitutions), F1245 (I/C), and R1275 (L/Q) in the kinase domain are three hotspots (Figure 2A) observed in ∼90% of mutated cases of neuroblastoma, for which the most frequent, F1174L and R1275Q, markedly enhance ALK autophosphorylation and activation [89].