ALK containing truncated extracellular domains triggering constitutive kinase activity have also been described in neuroblastoma [97,98], as well as a novel, recently discovered ALK fusion chimera with the teneurin transmembrane protein 3 (TENM3), arising from translocation within chromosome 2p and 4q that causes oncogenic transformation [99]. Here, TENM3 is linked to neuroblastoma.