CCR7 and neoplasm: Using an EGFRvIII+CT-2A tumor line expressing ZsGreen as a traceable antigen, we found that vaccine boosting triggered DC activation as evidenced by upregulation of the lymph node homing marker CCR7, costimulatory receptors, and MHC-II (Figure 6F, S6F–K), and increased tumor antigen uptake by both cDC1 and cDC2 populations (Figure 6G–H).