By contrast, CD4+ Th cells from CAR T-vax-treated mice upregulated genes associated with Th1 function (Ifng, Cxcr3) and self-renewal (Slamf6, Tcf7) (Figure 2F, S2D–E), suggesting that the vaccine may also promote anti-tumor phenotypes among CD4+ TILs. This evidence concerns the gene IFNG and neoplasm.