IFI16 mRNA expression did not differ at the early stages of infection but showed a significant difference in protein expression between WT and Usp12-/- BMDMs stimulated with HSV-1 (Fig 5C and 5D), CMV (S8B and S8C Fig) or poly(dA:dT) (S8D and S8E Fig). This evidence concerns the gene USP12 and infection.