FH and age-related macular degeneration: These findings are in line with recent studies in patients with AMD that also showed that the G allele of rs7535263 (and variants in strong LD with it) is associated with increased FHR-2, FHR-4, and FHR-5 levels.23,24,36,37 FHR-2, FHR-4, and FHR-5 have been shown to accumulate in the intercapillary septa of the choriocapillaris in AMD and to interrupt regulation of the complement cascade by competing with FH-binding sites.23 These observations are of interest for the understanding of the disease biology of idiopathic MFC.