The association of risk variants in CFH with circulating coagulation factors has also previously been reported in a plasma proteomic analysis in 4998 healthy blood donors, indicating that the here-described genetic predisposition in the extended CFH locus with altered levels of coagulation pathway factors is robust.38 The association between variants in CFH and coagulation pathway factors, such as prothrombin (F2), is not yet reported in large proteomic studies of AMD. Here, F2 is linked to age-related macular degeneration.