Vimentin ishighly expressed in aggressive epithelial cancers, inducing tumorcell migration, and is thus associated with increased metastasis rates.Our data (Figure 6)revealed that in particular, Ir1 markedly downregulatedthe vimentin expression, whereas already sub-toxic concentrationsof conventional doxorubicin considerably increased vimentin expressionin the cells, consistent with the ability of doxorubicin to enhancebreast cancer cell migration and invasion. This evidence concerns the gene NISCH and cancer.