The mobilization process relies on a variety of inflammatory mediators produced by tumor cells, including granulocyte–macrophage colony-stimulating factor, granulocyte colony-stimulating factor (G-CSF), macrophage colony-stimulating factor, stem cell factor, vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-10, and other transcription factors released that induce rapid myelopoiesis in both BM but also lymphoid nodules. This evidence concerns the gene IL6 and neoplasm.