NFKB1 and neoplasm: Furthermore, other pathways, including the tumor-derived exosome-associated protein HSP70 inducing MDSCs suppressive activity through TLR2/MyD88 signaling and autocrine IL-6 production (Condamine and Gabrilovich 2011; Martino et al. 2010; Millrud et al. 2017), as well as the activation of NF-κB pathway and other factors, such as IRF8 and Notch, have been implicated in the generation and functionality of these cells (Condamine et al. 2015; Netherby et al. 2017).