CD274 and neoplasm: In this sense, berberine, a natural component of traditional Chinese medicine (an isoquinoline quaternary alkaloid derived from Coptis chinensis), is capable of promoting the proteasome-dependent degradation of PD-L1 on tumor cells and thus increasing the intra-tumoral infiltrate of T cells accompanied by a decrease in MDSCs in a Lewis tumor xenograft mice (Liu et al. 2020).