PNPLA3 and liver disorder: Also of interest are genetic variants, such as the presence of gene polymorphisms, e.g. for patatin-like phospholipase domain-containing protein-3 (PNPLA3) and trans-membrane 6 superfamily 2 (TM6SF2) [10, 19, 35], which have been implicated in predisposing to the development and severity of liver disease in NAFLD [35–37].